长江武惠堤堤防渗透破坏风险计算模型及应用

针对渗透水压力引起堤防渗透破坏问题,以堤防渗透破坏风险为目标,考虑堤防计算水位条件和土层渗透系数的不确定性,建立了堤防渗透破坏风险计算模型。以长江武惠堤17+750断面为例,对汉口水文站水位监测资料进行分析并拟合水位概率密度函数,对该断面渗流规律进行有限元分析,从而拟合渗透破坏概率密度函数,以此建立该断面堤防渗透破坏风险定量表达式。研究结果表明,武惠堤17+750断面堤防在警戒水位与防洪设计水位下,渗透破坏概率分别为0.442 9、0.764 0,渗透破坏风险分别为0.001 421、0.002 52;堤防渗透破坏风险随着堤外水位的升高而增加,但在防洪设计水位内运行时,堤防渗透破坏风险低,堤防渗流安全可得到有效控制。     

Occurrence and risk assessment of mycotoxins,acrylamide, and furan in Latvian beer

This work reports data on the occurrence of nine mycotoxins and two food processing contaminants – acrylamide and furan – in a total of 100 beers produced in Latvia. Mycotoxins were detected by high-performance liquid chromatography (HPLC) coupled with time-of-flight mass spectrometry, acrylamide by HPLC coupled with quadrupole-Orbitrap mass spectrometry, and furan by headspace gas chromatography-mass spectrometry. The most frequently occurring mycotoxins were HT-2 and deoxynivalenol (DON), which were detected in 52% and 51% of the analysed samples. The highest content was observed for DON, reaching the maximum of 248 µg kg^?1. Furan was ubiquitous, and 74% of the samples contained acrylamide. In terms of the estimated exposure, the biggest potential risk was identified for HT-2 representing more than 11% of tolerable weekly intake. The margin of exposure approach indicated the exposure to furan through beer as significant, this parameter being close to the critical limit.     

青海省格尔木市西大滩东多金属矿控矿因素及找矿前景

青海省格尔木市西大滩东多金属矿出露地层主要为早-中三叠世昌马河地层走向呈北西~南东向,与区域构造线方向基本一致。是测区的主要矿源层,为后期矿化提供了物质基础。比较发育的北西向、北西西向逆断层具有明显的多期活动特点,多形成破碎带,为热液活动、成矿元素富集提供了良好空间,对本区矿化起着一定的控制作用,破碎蚀变带控制了土壤异常展布。本文对西大滩东多金属矿控矿因素及找矿前景进行分析探讨。     

基因芯片法在食源性疾病中诊断效果及影响多因素Logistic分析研究

目的对比基因芯片法在食源性疾病诊断中的效果,并对影响多因素进行logistic分析。方法选择180例临床表现符合食源性疾病诊断标准的患者作为研究对象,随机均分为实验组和对照组各90例,对照组采用传统的常规培养检测方法,实验组采用基因芯片法进行检测,对比2种方法的检出率、检测耗时以及检测灵敏度。结果实验组的检出率和检测灵敏度均高于对照组的检出率和检测灵敏度,对照组的检测耗时大约是实验组检测耗时的8.24倍。结论相比常规方法,应用基因芯片法的诊断速度更快、准确率更高,在诊断食源性疾病中的应用效果更佳。通过对单因素的χ~2和t检验,确定对食源性疾病有直接影响的多个因素。对影响食源性疾病的多个因素进行Logistic分析,分析结果表明在本次研究分析中,影响较大的因素是人们的饮食卫生以及进食规律。     

Quality-by-design approach for the development of telmisartan potassium tablets

A quality-by-design approach was adopted to develop telmisartan potassium (TP) tablets, which were bioequivalent with the commercially available Micardis^® (telmisartan free base) tablets. The dissolution pattern and impurity profile of TP tablets differed from those of Micardis^® tablets because telmisartan free base is poorly soluble in water. After identifying the quality target product profile and critical quality attributes (CQAs), drug dissolution, and impurities were predicted to be risky CQAs. To determine the exact range and cause of risks, we used the risk assessment (RA) tools, preliminary hazard analysis and failure mode and effect analysis to determine the parameters affecting drug dissolution, impurities, and formulation. The range of the design space was optimized using the face-centered central composite design among the design of experiment (DOE) methods. The binder, disintegrant, and kneading time in the wet granulation were identified as X values affecting Y values (disintegration, hardness, friability, dissolution, and impurities). After determining the design space with the desired Y values, the TP tablets were formulated and their dissolution pattern was compared with that of the reference tablet. The selected TP tablet formulated using design space showed a similar dissolution to that of Micardis^® tablets at pH 7.5. The QbD approach TP tablet was bioequivalent to Micardis^® tablets in beagle dogs.     

探究地质矿产勘查风险原因的分析及应对对策

我国有许多种类的地质矿产资源,地质矿产资源的勘查与开发有效地促进了我国工业生产的进步。整个社会的发展对于地质矿产资源的需求也非常高,所以必须开展高效的矿产资源勘查活动。但是目前地质矿产资源勘查中经常会存在一系列的风险,会对勘查人员及整个矿床造成不同程度的损害。相关企业必须采取有效的应对策略,有效降低企业的勘查风险。本文主要是基于地质矿产勘查风险原因的分析及应对策略两方面来展开进一步论述的。     

Structure of presented stimuli influences gazing behavior and choice

Well-structured stimuli presentation is essential in eye-tracking research to test predefined hypotheses reliably and to conduct relevant gazing behavior studies. Several bottom-up factors associated with stimuli presentation (such as stimuli orientation, size etc.) can influence gazing behavior. However, only a small number of scientific papers address these factors in a sensory and consumer science context and thus provide guidance to practitioners. The two presented eye-tracking studies on food images aimed at evaluating the effect of the bottom-up factors stimulus size, background of the picture, orientation of food product presentation, the evaluated products and the number of alternatives. Significant effects of product group were found in the case of all eye-movement parameters except time to first fixation and first fixation duration. In contrary, orientation significantly influenced only the time to first fixation and first fixation duration parameters. Stimulus size significantly increased fixation and dwell count, while background showed no significant effects. Furthermore, significant relationships were found between the number of presented images and eye-movement and decision time. Less time was needed in 2AFC (alternative forced choice test), 3AFC and 4AFC and significantly more time was needed to choose one alternative out of 7AFC and 8AFC. The results of the two studies show that the investigated bottom-up factors can significantly influence gazing behavior, and therefore need to be carefully considered when planning or comparing results of eye-tracking experiments.     

A hybrid artificial bee colony algorithm for flexible job shop scheduling with worker flexibility

The traditional flexible job shop scheduling problem (FJSP) considers machine flexibility but not worker flexibility. Given the influence and potential of human factors in improving production efficiency and decreasing the cost in practical production systems, we propose a mathematical model of an extended FJSP with worker flexibility (FJSPW). A hybrid artificial bee colony algorithm (HABCA) is presented to solve the proposed FJSPW. For the HABCA, effective encoding, decoding, crossover and mutation operators are designed, and a new effective local search method is developed to improve the speed and exploitation ability of the algorithm. The Taguchi method of Design of Experiments is used to obtain the best combination of key parameters of the HABCA. Extensive computational experiments carried out to compare the HABCA with some well-performing algorithms from the literature confirm that the proposed HABCA is more effective than these algorithms, especially on large-scale FJSPW instances.     

Optimizing PSMA Radioligand Therapy for Patients with Metastatic Castration-Resistant Prostate Cancer. A Systematic Review and Meta-Analysis

The aim of the review was to evaluate patient and treatment characteristics for patients with metastatic castration-resistant prostate cancer (mCRPC) treated with PSMA radioligand therapy (PRLT) associated with above-average outcome. The systematic review and meta-analysis followed recommendations by the Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA). We searched for publications in PubMed, Embase, and ClinicalTrials.gov up to 31 September 2020. Thirty-six publications and four duplicates reported 2346 patients. Nearly two-thirds of the patients had bone metastases. Median overall survival (OS) was 16 months. Asymptomatic patients and patients with only lymph node metastases lived longer than symptomatic patients and patients with more extensive metastases. Patients treated with an intensified schedule of ¹⁷⁷Lu PRLT lived longer than those treated with a conventional schedule. Half of the patients obtained a PSA decline ≥ 50% and these patients lived longer than those with less PSA decline. Approximately 10% of the patients developed hematologic toxicity with anemia grade 3 as the most severe adverse effect. Characteristics for patients, cancer, restaging, and PRLT predict above average overall survival following treatment with PRLT.